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Blue-Blooded Crabs at Heart of Pharma Dispute on Drug Testing

August 19, 2019

Zurich: Swiss biotech Lonza and U.S.-based Charles River Laboratories are the biggest suppliers of crab blood-based endotoxin tests, which detect bacterial contamination in intravenous drugs and medical implants. They are now at odds over the future of this testing, as Lonza urges adoption of a synthetic alternative called recombinant Factor C (rFC), amid pressure from wildlife campaigners and worries about supply reliability. Meanwhile, Charles River, which is still studying rFC, argues moving too quickly could compromise patient safety. download the pdf.