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How Horseshoe Crabs Are Saving Us from Healthcare-Associated Infections

July 20, 2017

Global: There are some newer tests that may replace at least the bacteria-detecting role of LAL and TAL, which are not made from horseshoe crab blood. One is recombinant factor C — synthetic version of Factor C, a clotting factor in horseshoe crab blood, from cloned DNA. Another uses human blood. It’s called the monocyte activation test (MAT), also known as the in-vitro pyrogen test, and it may eventually detect non-endotoxin bacteria that horseshoe crab blood can’t reveal. Scientists continue to develop those methods so they can be more reliable and widely used, while also searching for other alternatives. download the pdf.